The San Francisco 49ers will face the Tampa Bay Buccaneers in Week 6 without two of their key starters, quarterback Brock Purdy and wide receiver Ricky Pearsall, both sidelined by injuries. This significant blow to the lineup, alongside other inactive players, could impact the team’s performance as they aim to maintain their momentum in the season.

Brock Purdy Sidelined with Turf Toe
Brock Purdy, the 49ers’ starting quarterback, has been ruled out for the game due to a turf toe injury sustained earlier in the season. Purdy, who did not practice at all this week, will miss his second consecutive week of action. The team’s cautious approach this time around is a marked improvement from their initial handling of the injury. After Purdy first suffered the injury in Week 1, he was allowed to return to limited practice after just one week of rest, a decision that raised concerns given the severity of turf toe injuries.
The 49ers are now prioritizing Purdy’s long-term health, learning from examples like Cincinnati Bengals quarterback Joe Burrow, who required surgery for a similar injury. With Purdy out, Mac Jones, listed as questionable with knee and oblique issues, will step in as the starter, with Adrian Martinez serving as the backup. However, Jones himself is not fully healthy, and there’s a risk his condition could worsen with the physical demands of facing Tampa Bay’s defense. The 49ers are hopeful that this additional rest will bring Purdy closer to full recovery, ensuring he’s ready for the critical second half of the season.
Ricky Pearsall Out with PCL Injury
Joining Purdy on the inactive list is wide receiver Ricky Pearsall, who is nursing a PCL knee injury sustained in Week 4 against the Jacksonville Jaguars. The 49ers are taking a conservative approach with Pearsall, recognizing the importance of allowing him sufficient time to heal. This decision is informed by examples like Las Vegas Raiders tight end Brock Bowers, who played through a similar injury earlier this season, only to see his performance suffer significantly before being forced to miss games.

Pearsall has emerged as a vital component of the 49ers’ offensive scheme, and ensuring his full recovery is crucial for the team’s playoff aspirations. In his absence, quarterback Mac Jones will rely heavily on receivers like Kendrick Bourne and Jauan Jennings, the latter of whom is also listed as questionable but expected to play.
Additional Absences and Team Strategy
In addition to Purdy and Pearsall, the 49ers will be without defensive players Yetur Gross-Matos (knee/hamstring), Robert Beal (ankle), Jordan Watkins (calf), and Kevin Givens. These absences further challenge the team’s depth as they prepare to take on a Tampa Bay squad eager to capitalize on San Francisco’s depleted roster.
The 49ers’ decision to prioritize player health over short-term gains reflects a strategic focus on the long-term success of the season. By giving Purdy and Pearsall the time needed to recover fully, the team aims to have their key playmakers back at full strength for a crucial playoff push later in the year. For now, the 49ers will lean on their depth and resilience to navigate this challenging matchup against the Buccaneers.
As San Francisco prepares for Sunday’s game, all eyes will be on Mac Jones and the supporting cast to step up in the absence of two critical starters. The outcome of this game could set the tone for how the 49ers manage the rest of their injury-riddled season.